PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL)

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Citation:
Chemical Endpoint Value Endpoint Description Life Cycle Stage Sample Size Location Type California Counties Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) No effect Body weight Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) No effect Liver:body weight Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) See citation Liver histology Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased Survival to day 24 Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased Pipped egg Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased Hatching success Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased T4/mg thyroid Embryo 60 Toxicity Factor Datasets Lab Laboratory

Double-crested Cormorant (Phalacrocorax auritus)

Citation:

Effects of 3,3',4,4',5-pentachlorobiphenyl and 2,3,7,8-tetrachlorodibenzo-p-dioxin injected into the yolks of double-crested cormorant (Phalacrocorax auritus) eggs prior to incubation

Author(s)
Powell, Debra, Richard J. Aulerich, John C. Meadows, Don E. Tillitt, Mary E. Kelly, Kenneth L. Stromborg, Mark J. Melancon, Scott D. Fitzgerald, and Steven J. Bursian
Pages
2035-2040
Year
Issue
10
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) 177 ug/kg egg (77-264) LD50 (95% confidence limits) Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) no effect incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ all doses hepatic EROD activity in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) decreased @ 349 ug/kg egg spleen weights in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 175, 349, 698 ug/kg egg mortality in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory

American Kestrel (Falco sparverius)

Citation:

Polychlorinated biphenyl (PCB) effects on hepatic mixed function oxidases and porphyria in birds - II. American kestrel

Author(s)
Elliot, J.E., S.W. Kennedy, D. Jeffrey and L. Shutt
Pages
141-145
Year
Issue
1/2
Volume
99
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) increased with PCB 153 aminopyrine N-demethylase and aldrin epoxidase activities in liver Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) increased with PCB 105 aminopyrine N-demethylase activity in liver Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) increased with PCB 126 7-ethoxyresorufin O-deethylase and aldrin epoxidase activities in liver Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) no effect hepatic porphyrin levels Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) no effect liver weight Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) 2.4 (control), 119.0 (PCB 153), 182.0 (PCB 105), 3.3 (PCB 126) mg/kg, wet weight PCB concentrations in pooled adipose tissue Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
Citation:

Comparative developmental toxicity of planar polychlorinated biphenyl congeners in chickens, American kestrels, and common terns

Author(s)
Hoffman, David J., Mark J. Melancon, Patrice N. Klein, John D. Eisemann, and James W. Spann
Pages
747-757
Year
Issue
4
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) reduced @ 233 ng/g percent hatching success, percent pipped versus controls Not Reported Hatchling 24-26/treatment group Toxicity Factor Datasets hatchling Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) reduced @ 233 ng/g liver weight, radius and femur length versus controls Not Reported Hatchling 24-26/treatment group Toxicity Factor Datasets hatchling Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 2.3, 23, 233 ng/g incidence of malformations or edema, and EROD activity versus controls Not Reported Hatchling 24-26/treatment group Toxicity Factor Datasets hatchling Laboratory
Citation:

Comparative toxicity of polychlorinated biphenyls to Japanese quail (Coturnix c. japonica) and American kestrels (Falco sparverius)

Author(s)
Elliot, John E., Sean W. Kennedy, Angela Lorenzen
Pages
57-75
Year
Volume
51
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with PCB 77 liver weight (as percent of body weight) versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with Aroclor 1254 coproporphyrin levels in liver versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with PCB 77 liver ethoxyresorufin-O-deethylase activity versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) decreased with PCB 153 liver ethoxyresorufin-O-deethylase activity versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with PCB 126 liver ethoxyresorufin-O-deethylase activity versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
Citation:

Developmental Toxicity of PCB 126 (3,3',4,4',5-Pentachlorobiphenyl) in nestling American kestrels (Falco sparverius)

Author(s)
Hoffman, David J., Mark J. Melancon, Patrice N. Klein, Clifford P. Rice, John D. Eisemann, Randy K. Hines, James W. Spann, and Grey W. Pendleton
Pages
188-200
Year
Volume
34
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) decreased @ 250, 1000 ng/g bw body and organ growth versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 50,250,1000 ng/g bw incidence and severity of lesions in liver, spleen, bursa, thyroid versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased plasma enzyme activities indicative of hepatotoxicity versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) no effect hematocrit and hemoglobin values versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 50,250,1000 ng/g bw hepatic monooxygenase activities versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) in ng/g, wet wt: 156 (@ 50 ng/g), 380 (@ 250 ng/g), 1098 (@1000 ng/g) concentration in liver Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) positive correlation relationship between hepatic PCB 126 concentrations and ratio of oxidized to reduced glutathione Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
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