PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL)

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Citation:
Chemical Endpoint Value Endpoint Description Life Cycle Stage Sample Size Location Type California Counties Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) No effect Body weight Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) No effect Liver:body weight Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) See citation Liver histology Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased Survival to day 24 Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased Pipped egg Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased Hatching success Embryo 60 Toxicity Factor Datasets Lab Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) Decreased T4/mg thyroid Embryo 60 Toxicity Factor Datasets Lab Laboratory

Double-crested Cormorant (Phalacrocorax auritus)

Citation:
Author(s)
Powell, Debra, Richard J. Aulerich, John C. Meadows, Don E. Tillitt, Mary E. Kelly, Kenneth L. Stromborg, Mark J. Melancon, Scott D. Fitzgerald, and Steven J. Bursian
Pages
2035-2040
Year
Issue
10
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) 177 ug/kg egg (77-264) LD50 (95% confidence limits) Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) no effect incidence of developmental abnormalities, edema, body weight effects, spleen or gonad histopathologic anomalies, or sex ratio in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ all doses hepatic EROD activity in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) decreased @ 349 ug/kg egg spleen weights in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 175, 349, 698 ug/kg egg mortality in treated embryos versus controls Not Reported Embryo 83-86 eggs/treatment Lake Winnipegosis, Manitoba Toxicity Factor Datasets Laboratory

American Kestrel (Falco sparverius)

Citation:
Author(s)
Elliot, J.E., S.W. Kennedy, D. Jeffrey and L. Shutt
Pages
141-145
Year
Issue
1/2
Volume
99
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) increased with PCB 153 aminopyrine N-demethylase and aldrin epoxidase activities in liver Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) increased with PCB 105 aminopyrine N-demethylase activity in liver Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) increased with PCB 126 7-ethoxyresorufin O-deethylase and aldrin epoxidase activities in liver Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) no effect hepatic porphyrin levels Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) no effect liver weight Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
PCB 105 (2,3,3',4,4'-PENTACHLOROBIPHENYL), PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL) 2.4 (control), 119.0 (PCB 153), 182.0 (PCB 105), 3.3 (PCB 126) mg/kg, wet weight PCB concentrations in pooled adipose tissue Female Adult 5-6/group Toxicity Factor Datasets 1 yr Laboratory
Citation:
Author(s)
Hoffman, David J., Mark J. Melancon, Patrice N. Klein, John D. Eisemann, and James W. Spann
Pages
747-757
Year
Issue
4
Volume
17
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) reduced @ 233 ng/g percent hatching success, percent pipped versus controls Not Reported Hatchling 24-26/treatment group Toxicity Factor Datasets hatchling Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) reduced @ 233 ng/g liver weight, radius and femur length versus controls Not Reported Hatchling 24-26/treatment group Toxicity Factor Datasets hatchling Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 2.3, 23, 233 ng/g incidence of malformations or edema, and EROD activity versus controls Not Reported Hatchling 24-26/treatment group Toxicity Factor Datasets hatchling Laboratory
Citation:
Author(s)
Elliot, John E., Sean W. Kennedy, Angela Lorenzen
Pages
57-75
Year
Volume
51
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with PCB 77 liver weight (as percent of body weight) versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with Aroclor 1254 coproporphyrin levels in liver versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with PCB 77 liver ethoxyresorufin-O-deethylase activity versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) decreased with PCB 153 liver ethoxyresorufin-O-deethylase activity versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) increased with PCB 126 liver ethoxyresorufin-O-deethylase activity versus controls Female Adult 4/treatment group Toxicity Factor Datasets Laboratory
Citation:
Author(s)
Hoffman, David J., Mark J. Melancon, Patrice N. Klein, Clifford P. Rice, John D. Eisemann, Randy K. Hines, James W. Spann, and Grey W. Pendleton
Pages
188-200
Year
Volume
34
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) decreased @ 250, 1000 ng/g bw body and organ growth versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 50,250,1000 ng/g bw incidence and severity of lesions in liver, spleen, bursa, thyroid versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased plasma enzyme activities indicative of hepatotoxicity versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) no effect hematocrit and hemoglobin values versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) increased @ 50,250,1000 ng/g bw hepatic monooxygenase activities versus controls Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) in ng/g, wet wt: 156 (@ 50 ng/g), 380 (@ 250 ng/g), 1098 (@1000 ng/g) concentration in liver Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL) positive correlation relationship between hepatic PCB 126 concentrations and ratio of oxidized to reduced glutathione Not Reported Nestling 9-11/group Toxicity Factor Datasets Day 1-Day 10 Laboratory
OEHHA California Office of Environmental Health Hazard Assessment