EPN

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Displaying 15 data points

Mallard duck (Anas platyrhynchos)

Citation:

Neurotoxic and teratogenic effects of an organophosphorus insecticide (phenyl phosphorothioic acid-o-ethyl-o-[4-nitrophenyl] ester) on mallard development

Author(s)
Hoffman, David J. and Louis Sileo
Pages
284-294
Year
Volume
73
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
EPN decreased @ 12, 36 ug/g brain weight, protein content, acetylcholinesterase and neurotoxic esterase versus controls Not Reported Hatchling 12/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
EPN decreased @ 12 ug/g (82%); 36 ug/g (77%); 108 ug/g (70%) percent survival versus controls Not Reported Embryo 10/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
EPN decreased @ 12, 36, 108 ug/g brain weight, acetylcholinesterase activity, neurotoxic esterase activity versus controls Not Reported Embryo 10/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
EPN decreased @ 108 ug/g brain protein content versus controls Not Reported Embryo 10/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
EPN decreased @ 36 (cholineserase only), 108 ug/g plasma alkaline phosphatase, aspartate aminotransferase, cholinesterase activities, and uric acid Not Reported Embryo 12/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
EPN decreased @ 12, 36, 108 ug/g embryo weight and length, % normal survivors versus controls Not Reported Embryo 12/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
EPN decreased @ 12 ug/g (48%), 36 ug/g (29%), 108 ug/g (0%) % surviving to hatch versus controls Not Reported Hatchling 12/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
EPN decreased @ 12, 36 ug/g plasma cholinesterase activity, hemoglobin and uric acid content Not Reported Hatchling 12/group Toxicity Factor Datasets 72 hr of incubation (time of treatment) Laboratory
Citation:

Subchronic organophosphorus ester-induced delayed neurotoxicity in mallards

Author(s)
Hoffman, David J., Louis Sileo and Helen C. Murray
Pages
128-136
Year
Volume
75
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Age-Specific Lab
EPN decreased @ 90, 270 ppm food consumption and body weight compared with controls Female Juvenile 6/group Toxicity Factor Datasets 20 wks Laboratory
EPN increased @ all doses incidence of hyperactivity, ataxia, and/or paralysis compared with controls Female Juvenile 6/group Toxicity Factor Datasets 20 wks Laboratory
EPN increased @ 30, 90, 270 ppm incidence of CNS lesions (demyelination, axonal degeneration in spinal cord) compared with controls Female Juvenile 6/group Toxicity Factor Datasets 20 wks Laboratory
EPN decreased @ all doses activity of brain and plasma cholinesterase, and brain neurotoxic esterase compared with controls Female Juvenile 6/group Toxicity Factor Datasets 20 wks Laboratory
EPN decreased @ 90, 270 pmm plasma alkaline phosphatase activity compared with controls Female Juvenile 6/group Toxicity Factor Datasets 20 wks Laboratory

American Kestrel (Falco sparverius)

Citation:

Acute toxicity of four anticholinesterase insecticides to American kestrels, eastern screech owls, and northern bobwhites

Author(s)
Wiemeyer, Stanley N. and Donald W. Sparling
Pages
1139-1148
Year
Volume
10
Chemical Endpoint Value Endpoint Description Sex Life Cycle Stage Sample Size Location Type Lab
EPN 4.0 mg/kg bw (3.1-5.1 95% CI) LD50 Both Male and Female Adult 5/group Toxicity Factor Datasets Laboratory
EPN 68% (10.0 SD) mean brain cholinesterase depression (relative to control) in birds that died in 8 hrs post-dose Both Male and Female Adult 12 Toxicity Factor Datasets Laboratory
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