AROCLOR 1254
American Kestrel (Falco sparverius)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254, MIREX | 73.3% increase @ 8ppm mirex + 33 ppm Aroclor | semen volume | Male | Adult | 5-10/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, MIREX | 20.3% decrease @ 8 ppm mirex + 33 ppm Aroclor | sperm concentration | Male | Adult | 5-10/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, MIREX | no effect | sperm motility | Male | Adult | 5-10/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | 21.5-22.6% decrease @ 33 ppm | sperm concentration | Male | Adult | 10/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | no effect | sperm motility | Male | Adult | 10/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with Aroclor 1254 | coproporphyrin levels in liver versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 77 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | decreased with PCB 153 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 126 | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | increased after 4 or 12 weeks | aminopyrine N-demethylase and aldrin epoxidase activities versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | decreased after 4 weeks | liver ethoxyresorufin-O-deethylase activity versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, PCB 126 (3,3',4,4',5-PENTACHLOROBIPHENYL), PCB 153 (2,2',4,4',5,5'-HEXACHLOROBIPHENYL), PCB 77 (3,3',4,4'-TETRACHLOROBIPHENYL) | increased with PCB 77 | liver weight (as percent of body weight) versus controls | Female | Adult | 4/treatment group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254, POLYCHLORINATED DIBENZO-P-DIOXINS | increased @ 0.5, 5 ppm | in vitro microsomal breakdown of oestradiol | Both Male and Female | Adult | 4/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, POLYCHLORINATED DIBENZO-P-DIOXINS | increased @ 5 ppm | amount of liver cytoplasmic RNA | Both Male and Female | Adult | 4/group | Toxicity Factor Datasets | Laboratory |
Mallard duck (Anas platyrhynchos)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254, DDE (4,4'-) | decreased with all treatments | numbers of mammillary cores and basal caps on eggshell membranes versus controls | Female | Adult | 6-8 eggs/group from 10 hens | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | significant effect | PCB treatment altered the shape of the body weight growth curve but not the asymptotic weight | Both Male and Female | Juvenile | 15/dose | Toxicity Factor Datasets | 1d at initiation | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Age-Specific | Lab |
---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | increased @ 100, 250, 500 mg/kg bw | thyroid wt/body wt and liver wt/body wt ratios versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory | |
AROCLOR 1254 | increased @ 20,100, 250, 500 mg/kg bw | hepatic microsomal EROD and PROD activities versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory | |
AROCLOR 1254 | decreased @ 20, 100, 250, 500 mg/kg bw | plasma triiodothyronine concentrations versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory | |
AROCLOR 1254 | no effect | leukocyte counts, plasma biochemistry, corticosterone concentration versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory | |
AROCLOR 1254 | increased @ 250, 500 mg/kg bw | lymphocyte proliferation to PHA versus controls | Male | Adult | 6-12/dose | Toxicity Factor Datasets | 1-2 yr | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | no effect | food consumption rate (184 g/d) compared to control (173 g/d) | Female | Adult | 10/dose | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, DDE (4,4'-) | no effect | food consumption rate (181 g/d) compared to control (173 g/d) | Female | Adult | 10/dose | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | no effect | eggshell thickness | Female | Adult | 10 hens/dose; 8-9 eggs/dose | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, DDE (4,4'-) | 19% decrease | eggshell thickness, compared to control | Female | Adult | 10 hens/dose; 8 eggs/dose | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, DDE (4,4'-) | see citation | figure of # eggs/female/wk over time | Female | Adult | 10/dose | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254, DDE (4,4'-) | 344 (95% CL; 156-686) ppm DDE lipid basis and 346 (95%CL; 133-686) ppm PCB lipid basis @ 40 ppm DDE + 40 ppm PCB diet | mean DDE and PCB residue levels in eggs | Female | Adult | 13 | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | no effect | reproductive success or nest attentiveness versus controls | Both Male and Female | Adult | 22 pairs | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | no effect | body and liver weights of parents and offspring versus controls | Both Male and Female | Both Adults and Juveniles | 22 pairs | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | 55-65 ppm | range of wet wt concentrations of Aroclor 1254 in adult carcasses | Both Male and Female | Adult | 22 pairs | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | 29.5(1.4) ppm | mean(SE) wet wt concentrations of Aroclor 1254 in carcasses of 3 week old ducklings | Not Reported | Juvenile | 10 | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | 23.3(1.0) ppm | mean(SE) wet wt concentrations of Aroclor 1254 in eggs | Not Reported | Embryo | 19 eggs | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | decreased @ 1000 mg/kg bw | post-dose eggshell thickness versus pre-dose thickness | Female | Adult | 5/group | Toxicity Factor Datasets | Laboratory |
Mourning Dove (Zenaida macroura)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | increased at 10 ppm | interval from nest occupation to egg-laying | Female | Adult | 10-13/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | decreased at 10 ppm | percent of birds that laid eggs | Female | Adult | 10-13/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | no effect | progesterone concentration in blood | Female | Adult | 10-13/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | earlier @ 10 ppm | timing of peak progesterone concentration in blood | Female | Adult | 10-13/group | Toxicity Factor Datasets | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Condition | Lab |
---|---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | increased at 10, 40 ppm | length of courtship period | Both Male and Female | Adult | 8/group | Toxicity Factor Datasets | breeding | Laboratory | |
AROCLOR 1254 | decreased at 40 ppm | courtship behavior score (intensity) | Both Male and Female | Adult | 8/group | Toxicity Factor Datasets | breeding | Laboratory | |
AROCLOR 1254 | decreased at 10, 40 ppm | number of pairs nesting | Both Male and Female | Adult | 8/group | Toxicity Factor Datasets | breeding | Laboratory | |
AROCLOR 1254 | delayed at 10 ppm | onset of nest initiation | Both Male and Female | Adult | 8/group | Toxicity Factor Datasets | breeding | Laboratory |
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type | Lab |
---|---|---|---|---|---|---|---|---|
AROCLOR 1254 | no effect | metabolic rate at a range of ambient temperatures | Male | Adult | 4/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | no effect | body weight | Male | Adult | 10/group | Toxicity Factor Datasets | Laboratory | |
AROCLOR 1254 | decreased at 40 ppm | body temperature at a range of ambient temperatures | Male | Adult | 4/group | Toxicity Factor Datasets | Laboratory |
Great Horned Owl (Bubo virginianus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|---|
AROCLOR 1254, DDE (4,4'-), DIELDRIN, HEPTACHLOR EPOXIDE, OXYCHLORDANE | 5% decrease | eggshell thickness index compared with reference eggs | Female | Adult | 18 eggs, 15 clutches | Butler, Delaware, Hamilton Counties | Toxicity Factor Datasets |
Brown Pelican (Pelecanus occidentalis)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|---|
AROCLOR 1254, DDD (4,4'-), DDE (4,4'-), DDT (4,4'-), DIELDRIN | 0.896 ppm DDE, 0.256 ppm DDD, 0.166 ppm DDT, 0.208 dieldrin, 2.241 ppm PCB 1254 | mean residues in eggs | Female | Adult | 29 eggs | east coast | Toxicity Factor Datasets |
Peregrine Falcon (Falco peregrinus)
Chemical | Endpoint Value | Endpoint Description | Sex | Life Cycle Stage | Sample Size | Location | Type |
---|---|---|---|---|---|---|---|
AROCLOR 1248, AROCLOR 1254, AROCLOR 1260, DDE (4,4'-), DDT (4,4'-), MERCURY COMPOUNDS | no effect | eggshell thickness compared to pre-1947 reference eggs | Female | Adult | 9 eggs | urban nest sites | Toxicity Factor Datasets |